Posts Tagged: depression

Researchers identify new type of depression

Researchers identify new type of depression

Protein linked with depression shows promise as new drug target     Depression is a mental disorder that affects over 300 million people around the world. While treatments exist, many of them are based on one hypothesis of how depression arises. Patients that do not fit this mold may not be getting benefits. A study led by Hiroshima University (HU), which was published online┬áthis May in Neuroscience, shed light on how one protein called RGS8 plays a role in depression behaviors. Scientists think depression occurs because of the monoamine hypothesis, so named for the type of two chemicals that depressed people lack: serotonin and norepinephrine (NE). Ninety percent of antidepressant… Read more

A study of antidepressants reveals how treatment helps depression management

A study of antidepressants reveals how treatment helps depression management

  Researchers in Japan have shown that several different classes of antidepressants increase early growth responses in astrocytes, star-shaped glial cells, which could help develop new treatments. Amitriptyline is a prototypical antidepressant that is currently used worldwide. Generally, effects of antidepressants such as amitriptyline in depressive patients become evident after treatment for a few weeks. However, no study has investigated the reasons why effects are not immediately evident. Previous studies have shown that amitriptyline increases the mRNA expression of fibroblast growth factor 2 (FGF2) in rat astrocytes, not neurons, slowly over 24 hours. However, the cellular mechanism that leads to the expression of FGF2 following amitriptyline treatment remains unclear. In… Read more