Posts Tagged: Research Institute for Radiation Biology and Medicine

Transcription factor helps tumors grow in low oxygen, resist anticancer therapies

Transcription factor helps tumors grow in low oxygen, resist anticancer therapies

  An international team of researchers found how cancer cells respond to DNA damage signaling when in low oxygen, or hypoxia. Through comprehensive gene expression analyses, the team determined how one family of genes controls DNA damage response, as well as how it weakens the effectiveness of anticancer therapies. Our bodies have strict molecular mechanisms that help us respond to hypoxia. These mechanisms are not just limited to helping us adapt to higher altitudes when climbing up a mountain. They also arise in diseases such as anemia, diabetes, or cancers. In the case of a new study led by Keiji Tanimoto‚Äôs team at Hiroshima University (HU), hypoxia indicates developments or… Read more