Posts Tagged: biochemistry

Kazunori Imaizumi, biochemistry

Kazunori Imaizumi, biochemistry

A Conversation with Distinguished Professor Kazunori Imaizumi A Common Cause Inside the cells of animals and plants is a folded, flattened tube of membranes piled on top of themselves. Studded along portions of the inside of this tube are ribosomes, small organelles that turn messages from DNA into protein. The proteins and occasionally important fats, or lipids, travel through the tube, folded and finalized into their completed form as they go. The tube itself is the Endoplasmic Reticulum, referred to as “the ER” by scientists. If something goes awry within the ER, proteins and lipids can get backed-up, clogging the tube and causing cellular stress. Both the potential causes and… Read more

A microbial metabolite of linoleic acid ameliorates intestinal inflammation

A microbial metabolite of linoleic acid ameliorates intestinal inflammation

Inflammatory bowel diseases (IBDs), including Crohn disease and ulcerative colitis, are hard to completely cure. Globally, IBDs affect more than 4 million people, today. However, Professor Soichi Tanabe (Graduate School of Biosphere Science, Hiroshima University) and his collaborators have demonstrated that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has a suppressive effect on intestinal inflammation. HYA is expected to be practically applied as a functional food. The results of this group’s research were published in The Journal of Biological Chemistry as “A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway” DOI: 10.1074/jbc.M114.610733. IBD patients characteristically demonstrate increased expression of tumor… Read more