Posts Tagged: cancer

A fuse of cardiovascular diseases

A fuse of cardiovascular diseases

  A promising biomarker for the severity of age-related white matter changes (ARWMCs) and endothelial function was evaluated at Hiroshima University, Japan. The relationship between this biomarker, the telomeric 3′-overhang (G-tail) length, and cardiovascular risk in humans is unclear so far. The researchers at Hiroshima University investigated the association between the telomere G-tail length of leukocytes and vascular risk, ARWMCs, and endothelial function. They suggested that the telomere G-tail might be a useful marker of endothelial dysfunction, as well as stroke and dementia. Telomeres are the structures that cap each end of a chromatid, at the extreme end of the chromosomal DNA. Telomeres are composed of double-stranded DNA with terminal… Read more

Noncoding RNA CCDC26 regulates KIT expression

Noncoding RNA CCDC26 regulates KIT expression

  A long noncoding RNA (lncRNA), which might give an impact on tyrosine kinase-targeted leukemia therapy, was found to be expressed in a leukemia cell line. The function of the lncRNA CCDC26 is not fully understood; however, researchers at Hiroshima University revealed the mechanisms by which CCDC26 controls the receptor tyrosine kinase KIT expression. The results provide new insights into leukemia recurrence and may help to develop new leukemia therapies. Recent transcriptomic studies have revealed the existence of numerous RNAs that are relatively long but not translated into proteins. Some of such lncRNAs are suggested to regulate the expression of other genes. Mutations or imbalances in the noncoding RNA repertoire… Read more