Posts Tagged: cell biology

Family dynamics: molecules from the same family have different effects in cancer prognosis

Family dynamics: molecules from the same family have different effects in cancer prognosis

Scientists observe that one molecule increases liposarcoma tumor cell spread and aggression while another molecule from the same family decreases migration and cell proliferation. Researchers at Hiroshima University have found that different levels of two molecules of the same family—TIMP-1 and TIMP-4—can influence prognosis of liposarcoma. High levels of TIMP-1 lead to a poor prognosis while high TIMP-4 indicates a less severe form of liposarcoma. This study, published in Carcinogenesis 10th May, described the molecules’ mechanism of action through the YAP/TAZ pathway. Further research can lead to new treatments and better methods of diagnosis for liposarcoma. Different types of cancer have different prognoses (medical outcomes) and some are easier to… Read more

The ups and downs of transportation within cells

The ups and downs of transportation within cells

New role for Rab6 How do cells avoid growing topsy-turvy?  Growing so your top, front, bottom and back all wind up on the correct side requires a good sense of direction at the cellular level.  A Hiroshima University research group has identified a familiar gene with an unexpected role in directing proteins around the cell. “I really want to figure out how proteins know where to go inside the cell.  The 2013 Nobel Prize in Physiology or Medicine was awarded to researchers who laid the groundwork for understanding transportation within cells, but the process of how different proteins are sorted to go to different locations is still unknown,” said Akiko… Read more