Posts Tagged: cellular biology

How is the membrane protein folded?

How is the membrane protein folded?

From molecular biology toward new medical care A key factor in the biosynthesis and stable expression of multi-pass transmembrane proteins was discovered, and its loss is thought to cause retinal degeneration. The factor works especially for multi-pass membrane proteins, in the integration of polypeptides into the membrane and/or protein folding. Understanding the mechanisms underlying protein folding and trafficking may contribute to the large-scale, therapy-based production of target proteins. In 2013, the Nobel Prize in Physiology or Medicine was awarded to Randy W. Schekman, James E. Rothman, and Thomas C. Südhof for their discovery of how cells deliver thousands of membrane proteins to the right place at the right time. It… Read more

International conference on the 4-dimensional organization of the nucleus

International conference on the 4-dimensional organization of the nucleus

‘The 4-D Nucleome 2014’ will be held in Hiroshima, Japan In 1944, Nobel Prize-winning physicist Erwin Schrödinger published a book entitled “What Is Life?” in Ireland. Seventy years later, you might get a hint of the answer by exploring the world of “4D Nucleome” in Japan. The latest advances in understanding the principles behind the three-dimensional organization of the cell nucleus in space and time (the 4th dimension) will be presented at an international conference, “The 4D Nucleome 2014,” in Hiroshima, Japan, from December 17 to 20, 2014. The conference will be hosted by the Research Center for the Mathematics on Chromatin Live Dynamics (RCMCD) of Hiroshima University. The conference… Read more

Establishment of induced pluripotent stem cells from Werner syndrome fibroblasts

Establishment of induced pluripotent stem cells from Werner syndrome fibroblasts

Milestone for understanding diseases and for the development of new therapies Associate Professor Akira Shimamoto and Professor Hidetoshi Tahara at the Graduate School of Biomedical & Health Science in Hiroshima University, Professor Koutaro Yokote at the Graduate School of Medicine in Chiba University, Visiting Professor Makoto Goto at the Medical Center East in Tokyo Women’s Medical University, and collaborators including the staff at the Cancer Chemotherapy Center in the Japanese Foundation for Cancer Research, Tottori University, and Keio University established induced pluripotent stem (iPS) cells from the fibroblasts of Werner Syndrome patients. These results were published in PLOS ONE in an article entitled “Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells… Read more