Posts Tagged: Institute of Biomedical and Health Sciences

A Japanese multicenter clinical study on the prevention of stroke recurrence by statin

A Japanese multicenter clinical study on the prevention of stroke recurrence by statin

The results of “The Japan Statin Treatment Against Recurrent Stroke (J-STARS)” study led to the hypothesis that statins reduce the occurrence of strokes due to larger artery atherosclerosis. J-STARS examined whether pravastatin, a traditional statin widely used in the clinic, reduces the recurrence of strokes and respective subtypes in non-cardioembolic stroke patients. The study also… Read more

Studying cancer DNA in blood may help personalize treatment in liver cancer

Studying cancer DNA in blood may help personalize treatment in liver cancer

  Fragments of cancer DNA circulating in a patient’s bloodstream could help doctors deliver more personalized treatment for liver cancer, Japanese researchers report. The new research may help address a particular challenge posed by liver cancers, which can be difficult to analyze safely. One serious risk of existing biopsy methods is that doctors who want… Read more

New model for hepatitis B helps identify potential new therapeutic approach

New model for hepatitis B helps identify potential new therapeutic approach

A promising new avenue for treating hepatitis B has been reported by researchers at Hiroshima University who have developed a new animal model of the disease. About two million people worldwide have been exposed to hepatitis B virus. Liver transplantation is often necessary to save the lives of patients who have severe liver damage that… Read more

Sendai virus defends against a threat

Sendai virus defends against a threat

A research group at Hiroshima University demonstrated the mechanism by which the Sendai virus (SeV) escapes the host immune system. The researchers examined the crystal structure of the complex of SeV C protein and transcription factor STAT1, and found that SeV C protein inhibits the signal transduction pathway of interferon gamma. This discovery will allow… Read more

A study of antidepressants reveals how treatment helps depression management

A study of antidepressants reveals how treatment helps depression management

  Researchers in Japan have shown that several different classes of antidepressants increase early growth responses in astrocytes, star-shaped glial cells, which could help develop new treatments. Amitriptyline is a prototypical antidepressant that is currently used worldwide. Generally, effects of antidepressants such as amitriptyline in depressive patients become evident after treatment for a few weeks…. Read more

New molecular mechanism of neuropathic pain in mice

New molecular mechanism of neuropathic pain in mice

  The downregulation of spinal astrocyte connexin43 (Cx43) expression causes sustained neuropathic pain following peripheral nerve injury. The inflammatory cytokine tumor necrosis factor (TNF) mediates the downregulation of Cx43 expression, which leads to decreased expression of the glutamate transporter GLT-1 and enhanced glutamatergic neurotransmission. Targeting the recovery of Cx43 function using pharmacological approaches or gene… Read more