Posts Tagged: Institute of Biomedical and Health Sciences

New understanding of genetic susceptibility to infections by Candida and Mycobacterium

New understanding of genetic susceptibility to infections by Candida and Mycobacterium

  The discovery of bi-allelic mutations in RORC in patients with candidiasis and mycobacteriosis revealed the pivotal role of RORC in mucocutaneous immunity to Candida and in systemic immunity to Mycobacterium in humans. Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis (CMC), which is characterized by chronic or recurrent infections of the skin, nails, and oral and… Read more

The new detection method for a key drug resistant hepatitis C virus mutation

The new detection method for a key drug resistant hepatitis C virus mutation

A rapid, sensitive, and accurate method to detect drug resistant hepatitis C virus (HCV) mutants has been developed. Researchers at Hiroshima University established a system to rapidly and accurately measure the presence of HCV Y93H drug resistant mutant strains, and evaluate the proportion of patients harboring this mutation prior to treatment. Even in serum samples… Read more

A fuse of cardiovascular diseases

A fuse of cardiovascular diseases

  A promising biomarker for the severity of age-related white matter changes (ARWMCs) and endothelial function was evaluated at Hiroshima University, Japan. The relationship between this biomarker, the telomeric 3′-overhang (G-tail) length, and cardiovascular risk in humans is unclear so far. The researchers at Hiroshima University investigated the association between the telomere G-tail length of… Read more