Posts Tagged: medicine

A study of antidepressants reveals how treatment helps depression management

A study of antidepressants reveals how treatment helps depression management

  Researchers in Japan have shown that several different classes of antidepressants increase early growth responses in astrocytes, star-shaped glial cells, which could help develop new treatments. Amitriptyline is a prototypical antidepressant that is currently used worldwide. Generally, effects of antidepressants such as amitriptyline in depressive patients become evident after treatment for a few weeks…. Read more

New understanding of genetic susceptibility to infections by Candida and Mycobacterium

New understanding of genetic susceptibility to infections by Candida and Mycobacterium

  The discovery of bi-allelic mutations in RORC in patients with candidiasis and mycobacteriosis revealed the pivotal role of RORC in mucocutaneous immunity to Candida and in systemic immunity to Mycobacterium in humans. Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis (CMC), which is characterized by chronic or recurrent infections of the skin, nails, and oral and… Read more

A fuse of cardiovascular diseases

A fuse of cardiovascular diseases

  A promising biomarker for the severity of age-related white matter changes (ARWMCs) and endothelial function was evaluated at Hiroshima University, Japan. The relationship between this biomarker, the telomeric 3′-overhang (G-tail) length, and cardiovascular risk in humans is unclear so far. The researchers at Hiroshima University investigated the association between the telomere G-tail length of… Read more

Noncoding RNA CCDC26 regulates KIT expression

Noncoding RNA CCDC26 regulates KIT expression

  A long noncoding RNA (lncRNA), which might give an impact on tyrosine kinase-targeted leukemia therapy, was found to be expressed in a leukemia cell line. The function of the lncRNA CCDC26 is not fully understood; however, researchers at Hiroshima University revealed the mechanisms by which CCDC26 controls the receptor tyrosine kinase KIT expression. The… Read more

A microbial metabolite of linoleic acid ameliorates intestinal inflammation

A microbial metabolite of linoleic acid ameliorates intestinal inflammation

Inflammatory bowel diseases (IBDs), including Crohn disease and ulcerative colitis, are hard to completely cure. Globally, IBDs affect more than 4 million people, today. However, Professor Soichi Tanabe (Graduate School of Biosphere Science, Hiroshima University) and his collaborators have demonstrated that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has a suppressive effect… Read more

Establishment of induced pluripotent stem cells from Werner syndrome fibroblasts

Establishment of induced pluripotent stem cells from Werner syndrome fibroblasts

Milestone for understanding diseases and for the development of new therapies Associate Professor Akira Shimamoto and Professor Hidetoshi Tahara at the Graduate School of Biomedical & Health Science in Hiroshima University, Professor Koutaro Yokote at the Graduate School of Medicine in Chiba University, Visiting Professor Makoto Goto at the Medical Center East in Tokyo Women’s… Read more