Posts Tagged: neurology

Lasers, key to unlocking memory

Lasers, key to unlocking memory

New method uses near infrared light to shed light on memory loss conditions Researchers at Hiroshima University have developed a new laser activated technique for bridging missing links in memory flow. The brainchild of Professor Manabu Abe of Hiroshima Universities Department of Chemistry, it aims to open up the mysterious world of neurotransmission – increasing… Read more

The tortoise and the hare of spinal neural circuits

The tortoise and the hare of spinal neural circuits

After an injury, practicing movements at different speeds improves certain nerve functions Changes in one circuit of nerves, but not another, in the spinal cord depend on how quickly muscles must move to complete a task, according to results from the Human Motor Control Laboratory of Professor Kozo Funase, PhD, at Hiroshima University.  The results… Read more

New targets for reducing nerve pain identified

New targets for reducing nerve pain identified

A specific molecule involved in maintaining pain after a nerve injury has been identified and blocked in mice by Hiroshima University researchers.  These results reveal a promising therapeutic strategy for treating neuropathic pain. Mice with an injury to their sciatic nerve showed less pain after multiple injections of a drug that blocks the activity of… Read more

New molecular mechanism of neuropathic pain in mice

New molecular mechanism of neuropathic pain in mice

  The downregulation of spinal astrocyte connexin43 (Cx43) expression causes sustained neuropathic pain following peripheral nerve injury. The inflammatory cytokine tumor necrosis factor (TNF) mediates the downregulation of Cx43 expression, which leads to decreased expression of the glutamate transporter GLT-1 and enhanced glutamatergic neurotransmission. Targeting the recovery of Cx43 function using pharmacological approaches or gene… Read more