Posts Tagged: pain

New target for chronic pain relief confirmed by scientists

New target for chronic pain relief confirmed by scientists

Scientists observe drug target that can reduce pain when activated   A research group at Hiroshima University observed a potential new target for chronic pain treatment. Further research using this receptor could lead to new, more effective drugs to use in pain-relieving treatment for chronic pain. Conditions that cause chronic pain can be difficult to manage. These include sciatica, cancer and rheumatoid arthritis. Chronic pain mechanisms are complicated, which is one of the reasons why pain management is so difficult, explains Professor Norimitsu Morioka of the Department of Pharmacology, Graduate School of Biomedical & Health Sciences, Hiroshima University. This difficulty decreases the quality of life of patients that, in many cases, can suffer from… Read more

New targets for reducing nerve pain identified

New targets for reducing nerve pain identified

A specific molecule involved in maintaining pain after a nerve injury has been identified and blocked in mice by Hiroshima University researchers.  These results reveal a promising therapeutic strategy for treating neuropathic pain. Mice with an injury to their sciatic nerve showed less pain after multiple injections of a drug that blocks the activity of a molecule called high-mobility group box-1 (HMGB1).  Researchers also discovered that a single dose of a drug to block the activity of a different molecule, called matrix metalloprotease-9 (MMP-9), could also alleviate pain from the injury. The chemical pathways that these drugs use to inhibit HMGB1 or MMP-9 are different from common pain relievers, like… Read more

New molecular mechanism of neuropathic pain in mice

New molecular mechanism of neuropathic pain in mice

  The downregulation of spinal astrocyte connexin43 (Cx43) expression causes sustained neuropathic pain following peripheral nerve injury. The inflammatory cytokine tumor necrosis factor (TNF) mediates the downregulation of Cx43 expression, which leads to decreased expression of the glutamate transporter GLT-1 and enhanced glutamatergic neurotransmission. Targeting the recovery of Cx43 function using pharmacological approaches or gene therapy might serve as novel therapeutic strategies ameliorate neurological disorders in general and neuropathic pain in particular. Spinal cord astrocytes are critical in the maintenance of neuropathic pain. Cx43 expressed on spinal dorsal horn astrocytes modulates synaptic neurotransmission, but its role in nociceptive transduction has yet to be fully elaborated. Several types of Cx have… Read more