Posts Tagged: pain

New target for chronic pain relief confirmed by scientists

New target for chronic pain relief confirmed by scientists

Scientists observe drug target that can reduce pain when activated   A research group at Hiroshima University¬†observed a potential new target for chronic pain treatment.¬†Further research using this receptor could lead to new, more effective drugs to use in pain-relieving treatment for chronic pain. Conditions that cause chronic pain can be difficult to manage. These… Read more

New targets for reducing nerve pain identified

New targets for reducing nerve pain identified

A specific molecule involved in maintaining pain after a nerve injury has been identified and blocked in mice by Hiroshima University researchers.¬† These results reveal a promising therapeutic strategy for treating neuropathic pain. Mice with an injury to their sciatic nerve showed less pain after multiple injections of a drug that blocks the activity of… Read more

New molecular mechanism of neuropathic pain in mice

New molecular mechanism of neuropathic pain in mice

  The downregulation of spinal astrocyte connexin43 (Cx43) expression causes sustained neuropathic pain following peripheral nerve injury. The inflammatory cytokine tumor necrosis factor (TNF) mediates the downregulation of Cx43 expression, which leads to decreased expression of the glutamate transporter GLT-1 and enhanced glutamatergic neurotransmission. Targeting the recovery of Cx43 function using pharmacological approaches or gene… Read more