Posts Tagged: Research Center for the Mathematics on Chromatin Live Dynamics

Mathematical analysis reveals architecture of the human genome

Mathematical analysis reveals architecture of the human genome

Mathematical analysis has led researchers in Japan to a formula that can describe the movement of DNA inside living human cells. Using these calculations, researchers may be able to reveal the 3D architecture of the human genome. In the future, these results may allow scientists to understand in detail how DNA is organized and accessed… Read more

Active deformations of cell nuclei contribute to intra-nuclear architecture formations

Active deformations of cell nuclei contribute to intra-nuclear architecture formations

There are two types of chromatin, euchromatin and heterochromatin, that vary with the stages of the cell cycle. In particular, euchromatin with rich active genes localizes to the interior of the nucleus during interphase; heterochromatin usually localizes to the periphery of the nucleus. Akinori Awazu, an Associate Professor at the Research Center for Mathematics on… Read more

Protein machines make fluctuating flows unconsciously

Protein machines make fluctuating flows unconsciously

An international research group has demonstrated that protein machines, regardless of their specific functions, can collectively induce fluctuating hydrodynamic flows and substantially enhance the diffusive motions of particles in the cell. Biological cells contain large numbers of active proteins that repeatedly change their conformations. These protein machines have a variety of specific functions, acting as… Read more

Simultaneous live imaging of a specific gene’s transcription and dynamics

Simultaneous live imaging of a specific gene’s transcription and dynamics

The Real-time Observation of Localization and EXpression (ROLEX) system   Dr. Hiroshi Ochiai and his colleagues, Dr. Takeshi Sugawara (Research Center for the Mathematics on Chromatin Live Dynamics [RcMcD] at Hiroshima University) and Professor Takashi Yamamoto (Graduate School of Science at Hiroshima University), have established a novel live-imaging method termed the “Real-time Observation of Localization… Read more

International conference on the 4-dimensional organization of the nucleus

International conference on the 4-dimensional organization of the nucleus

‘The 4-D Nucleome 2014’ will be held in Hiroshima, Japan In 1944, Nobel Prize-winning physicist Erwin Schrödinger published a book entitled “What Is Life?” in Ireland. Seventy years later, you might get a hint of the answer by exploring the world of “4D Nucleome” in Japan. The latest advances in understanding the principles behind the… Read more